Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions
نویسندگان
چکیده
منابع مشابه
Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.
Deoxyribonucleic acid double-stranded breaks act as intermediates in Ig V(D)J recombination and probably perform a similar function in class switch recombination between IgH C genes. In SCID mice, V(D)J recombination is blocked because the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein is defective. We show in this study that switching to all isotypes examined was detectable ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2003
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.171.12.6556